Columbia University Medical Center

DEPARTMENT OF NEUROSCIENCE

Vikram Gadagkar, PhD

Vikram Gadagkar, PhD
  • Department of Neuroscience
  • Assistant Professor of Neuroscience (in the Mortimer B. Zuckerman Mind Brain Behavior Institute)

A major goal of neuroscience is to understand how the brain produces behavior. But to produce complex learned behavior, the brain first needs to evaluate behavior. The central question that drives the Gadagkar Lab is: How do brains evaluate behaviors - both self-generated and the behaviors of others? Many of our socially relevant motor skills such as speaking or playing a musical instrument are not innately programmed but are acquired and maintained through a process of trial and error or reinforcement. First, during the practice phase, these complex motor sequences are learned by matching exploratory motor output to internal goals or templates. Second, these newly acquired sequences are performed to a socially significant target audience in a highly stereotyped manner. Third, the audience evaluates the performance, shows a preference for certain features like stereotypy and virtuosity, and provides feedback to the performer. These three stages of practice, performance, and preference serve the goal of learning motor skills critical for social life, yet we understand very little about the neural mechanisms underlying these processes.

The songbird, with its highly tractable song circuit, is an excellent model system to address this problem. The adult zebra finch song is a learned, stereotyped motor sequence, and juvenile finches learn to imitate their tutor’s song (the internal goal) by trial and error. Furthermore, male songbirds ‘practice’ their songs alone with the ultimate goal of ‘performing’ to a female. Female finches evaluate male songs directed at them and show a ‘preference’ for the most stereotyped and attractive songs. The goal of the Gadagkar Lab is to combine the advantages of the zebra finch courtship song system with state-of-the-art computational, theoretical, and experimental techniques to study how the brain implements reinforcement learning through the stages of practice, performance, and preference. Some of the questions we are currently investigating are: 1. What is the role of reinforcement during early critical periods of sensorimotor learning? 2. How does the brain switch between a state optimized for variability and learning to a state optimized for stereotypy and performance? 3. What are the neural mechanisms of female mate choice?

Biography

Vikram Gadagkar is an Assistant Professor in the Department of Neuroscience and a Principal Investigator in the Mortimer B. Zuckerman Mind Brain Behavior Institute at Columbia University. Vikram received his BS in physics, chemistry, and mathematics from Bangalore University, MS in physics (working with Prof. Ajay Sood) from the Indian Institute of Science, and PhD in physics (working with Prof. Séamus Davis) from Cornell University. He then received his postdoctoral training with Prof. Jesse Goldberg at the Department of Neurobiology and Behavior, Cornell University, where he discovered that midbrain dopamine neurons encode performance error in singing birds.

Vikram joined Columbia University in May 2020.

Education & Training

  • BSc, 2002 Physics, Chemistry, Mathematics, St. Joseph's College, Bangalore University, India
  • MS, 2005 Physics , Indian Institute of Science (India)
  • PhD, 2013 Physics, Cornell University
  • Lab Locations

    Jerome L. Greene Science Center

    3227 Broadway
    L4-027
    New York, NY 10027

    Phone:
    (212) 853-1190
    Email:
    vg2481@columbia.edu

    Honors & Awards

    • 2018 Peter and Patricia Gruber International Research Award (Society for Neuroscience)
    • 2017 K99/R00 Pathway to Independence Award (NIH/NINDS)
    • 2016 Simons Collaboration on the Global Brain (SCGB) Postdoctoral Fellowship

    Lab Website

    Research Interests

    Cognitive/Systems neuroscience
    Neurobiology of Learning and Memory
    Systems and circuits
    Neuroethology
    Computation and theory

    Lab Members

    Publications

    Vikram Gadagkar, P. A. Puzerey, R. Chen, E. Baird-Daniel, A. Farhang and J. H. Goldberg (2016) Dopamine Neurons Encode Performance Error in Singing Birds. Science 354: 1278-1282

    Vikram Gadagkar and J. H. Goldberg (2013) A variability-generating circuit goes awry in a songbird model of the FOXP2 speech disorder. Neuron 80: 1341-1344

    E. Pratt, B. Hunt, Vikram Gadagkar, M. Yamashita, M. J. Graf, A. V. Balatsky, and J. C. Davis (2011) Interplay of Rotational, Relaxational, and Shear Dynamics of Solid 4He. Science 332: 821-824

    B. Hunt, E. Pratt, Vikram Gadagkar, M. Yamashita, A. V. Balatsky, and J. C. Davis (2009) Evidence for a Superglass State in Solid 4He. Science 324: 632-636