Columbia University Medical Center


Rene Hen, PhD

Rene Hen, PhD
  • Department of Psychiatry
    Division of Integrative Neuroscience
  • Department of Molecular Pharmacology and Therapeutics
  • Department of Neuroscience
  • Professor of Pharmacology (in Psychiatry)
  • Professor of Neuroscience

Director, Division of Integrative Neuroscience

Lab Locations

Kolb Research Annex

40 Haven Avenue
7th floor, Room 767
New York, NY 10032

(646) 774-7107


Member, Kavli Institute for Brain Science

Research Interests

Models of Psychiatric Disorders
Stem cell biology

Lab Members


  • Luna VM, Anacker C, Burghardt N, Khandaker H, Andreu V, Millette A, Leary P, Ravenelle R, Jimenez J, Mastrodonato A, Denny CA, Fenton A, Scharfman H, Hen R. (2019); Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs int the dentate gyrus. Science. 364(6440):578-583.
  • Anacker C., Luna V., Stevens G., Millette A., Shores R., Jimenez JC., Chen B., Hen R (2018); Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus;Nature
  • Donaldson ZR, Hen R. (2015). From psychiatric disorders to animal models: a bidirectional and dimensional approach. Biol Psychiatry. 77(1):15-21. PMCID: PMC4135025.
  • Denny CA, Kheirbek MA, Alba EL, Tanaka KF, Brachman RA, Laughman KB, Tomm NK, Turi GF, Losonczy A, Hen R. (2014). Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis. Neuron. 83(1):189-201. PMCID: PMC4169172.
  • Kheirbek MA, Hen R. (2014). Add neurons, subtract anxiety. Sci Am. 311(1):62-7. PMCID: PMC4165637.
  • Drew LJ, Fusi S, Hen R. (2013). Adult neurogenesis in the mammalian hippocampus: why the dentate gyrus? Learn Mem. 20(12):710-29. Review. PMCID: PMC3834622.
  • Kheirbek MA, Drew LJ, Burghardt NS, Costantini DO, Tannenholz L, Ahmari SE, Zeng H, Fenton AA, Hen R. (2013). Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron. 77(5):955-68. PMCID: PMC3595120.
  • Kheirbek MA, Klemenhagen KC, Sahay A, Hen R. (2012). Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat Neurosci.15(12):1613-20. PMCID: PMC3638121.
  • Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS, Fenton AA, Dranovsky A, Hen R. (2011). Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature. 472(7344):466-70. PMCID: PMC3084370.
  • Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O,Belzung C, Hen R. (2003). Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science, 301(5634): 805-9. PMID: 12907793.