Columbia University Medical Center

DEPARTMENT OF NEUROSCIENCE

Martin Picard, PhD

Martin Picard, PhD
  • Department of Psychiatry
    Division of Behavioral Medicine
  • Department of Neurology
    Division of Columbia Translational Neuroscience Initiative (CTNI)
  • Associate Professor of Behavioral Medicine (in Psychiatry and Neurology)

Columbia Translational Neuroscience Initiative (CTNI) Scholar

Biography

Martin Picard, PhD is the Herbert Irving Associate Professor of Behavioral Medicine (in Psychiatry and Neurology). Dr. Picard received his BSc Honours in neuroimmunology at McGill University where he remained for his graduate work in mitochondrial biology of aging. Dr. Picard then moved to the University of Pennsylvania for a postdoctoral fellowship in the Center for Mitochondrial and Epigenomic Medicine with Doug Wallace. There, he worked on mitochondria-mitochondria interactions, mitochondrial reprogramming of the nuclear (epi)genome, and mitochondrial stress pathophysiology along with Bruce McEwen. In 2015, he joined the faculty of Columbia University.

Dr. Picard’s translational research program investigates mechanisms of mitochondrial psychobiology. Investigators and trainees in the Mitochondrial Signaling Lab team combine genetic, cellular, imaging, and psychophysiology approaches to examine how psychosocial exposures impact mitochondrial structure and functions, and how energetic perturbations within mitochondria influence key brain-body processes involved in cognition, psychological stress reactivity, and resilience. Their work leverages computational and network approaches based on machine learning to capture molecular patterns of mitochondrial dysregulation across tissues, from organelle to organism.

Education & Training

  • PhD, 2012 Mitochondrial biology of aging, McGill University
  • Fellowship: University of Pennsylvania
  • Primary Lab Locations

    NYSPI-Kolb Research Building

    40 Haven Avenue
    4th floor, Room 405
    New York, NY 10032

    Lab Phone:
    (646) 774-5026
    Email:
    mp3484@columbia.edu

    CUMC/Presbyterian Hospital and Vanderbilt Clinic

    622 West 168th Street
    PH 1540 N
    New York, NY 10032

    Phone:
    (646) 774-8967
    Email:
    mp3484@columbia.edu

    Contact Information

    Honors & Awards

    2006 Alvin Shrier Physiology Scholarship, McGill University, Department of Physiology
    2008 Masters Training Scholarship, Fonds de Recherche en Sante du Quebec
    2008 Alexander Graham Bell Canada Masters Graduate Scholarship, NSERC
    2009 Alexander Graham Bell Canada Doctoral Graduate Scholarship, NSERC
    2009 McGill Provost’s Graduate Fellowship, McGill University
    2011 Age+ Prize, Canadian Institute of Health Research
    2011 David L. Montgomery Award for Leadership and Excellence, McGill University
    2011 Prix Acfas Desjardins 2011 (Doctoral, All disciplines), ACFAS
    2012 Journal of Cell Science Traveling Fellowship, Journal of Cell Science (London)
    2013 Young Investigator Colloquium Award, American Psychosomatic Society
    2015 Fellow, Gray Matters at Columbia
    2017 Research Fellow, Columbia University Aging Center
    2017 Herbert Irving Scholar, Columbia Irving Institute
    2019 Neal E Miller New Investigator Award (ABMR)
    2019 NIH Rising Stars Lecture

    Languages

    French

    Research Interests

    Mitochondrial Psychobiology
    Cellular Signaling
    Mitochondrial Synapses and Network Behavior
    Stress Pathophysiology
    Epigenetics
    Systems Biology
    Mitochondrial Disease
    Mitochondrial Nanotunnels

    Lab Members

    Publications

    Sturm G, Cardenas A,​ Bind MA,​ Horvath S, Wang S,​ Wang Y,​ Hagg S, Hirano M,​ Picard M. Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts. Epigenetics 2019; 14(10):961-976

    Trumpff C, Marsland AL, Basualto C, Martin JL, Carroll JE, Sturm G, Gu Z, Vincent A, Kaufman BA, Picard M. Acute psychological stress increases serum circulating cell-free mitochondrial DNA. Psychoneuroendocrinol 2019; 106:268-276

    Picard M, Trumpff C, Burelle Y. Mitochondrial psychobiology: Foundation and applications. Curr Opin Behav Sci 2019; 28:142-151

    Picard M, McEwen BS, Epel ES, Sandi C. An energetic view of stress: Focus on mitochondria. Front Neuroendocrinol 2018; 49:72-85

    Eisner V, Picard M, Hajnoczky G. Mitochondrial dynamics in adaptive and maladaptive cellular stress responses. Nat Cell Biol 2018; 20(7):655-665

    Picard M, Wallace DC, Burelle Y. The rise of mitochondria in medicine. Mitochondrion 2016; 30:105-16.

    Picard M, McManus MJ, Gray J, Nasca C, Moffat C, Kopinsky P, Seifert E, McEwen BS, Wallace DC. Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory and transcriptional responses to psychological stress. PNAS 2015; 112(48):E6614-23.

    Picard M, Zhang J, Hanecock S, Derbeneva O, Golhar R, Golik P, O’Hearn S, Levy SE, Potluri P, Lvova M, Davila A, Lin CS, Perin JC, Rappaport EF, Hakonarson H, Trounce I, Procaccio V, Wallace DC. Progressive increase in mtDNA 3243A>G heteroplasmy results in abrupt transcriptional remodeling. PNAS 2014; 111(38):E4033;4042.