Columbia University Medical Center


Claudia Schmauss, MD

Claudia Schmauss, MD
  • Department of Psychiatry
    Division of Molecular Therapeutics
  • Associate Professor of Psychiatry

Vice Chair, Institutional Animal Care and Use Committee at Columbia University

We are interested in unraveling molecular mechanisms underlying gene expression changes in psychopathological states.

The main focus of our research is on the role of gene x environment interaction in modulating adult behavioral phenotypes. We are conducting molecular, anatomic, and behavioral studies on animal models of depression-like behaviors and animal models of cognitive dysfunctions to study the role of epigenetic changes in gene expression in psychopathological states.

Primary Lab Locations

Herbert Pardes Building of the New York State Psychiatric Institute

1051 Riverside Drive
Unit 62
New York, NY 10032

(646) 774-8710


Society for Neuroscience, member

American Association for the Advancement of Science, member

Honors & Awards


1987                Otto Hahn Research Award sponsored by the Max Planck Society, Germany 

1996                Irma T. Hirschl Career Scientist Award

2001                Essel Investigator (NARSAD)

2004                Lieber Investigator (NARSAD)



Past Positions

1991-1996 - Assistant Professor, Department of Psychiatry and Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY

1997-1998 - Associate Professor, Department of Psychiatry and Brookdale Center for Molecular and Developmental Biology, Mount Sinai School of Medicine, New York, NY

1998-2005 - Associate Professor of Psychiatry, Department of Psychiatry, Columbia University, New York NY

1998-present - Research Scientist V, New York State Psychiatric Institute, New York, NY

2005-present - Associate Professor of Psychiatry (tenured), Department of Psychiatry, Columbia University, New York, NY

Research Interests

Models of Psychiatric Disorders
Cognitive/Systems neuroscience

Lab Members


  • Schmauss, C. (2015). An HDAC-dependent epigenetic mechanism that enhances the efficacy of the antidepressant drug fluoxetine. Sci. Rep. 5, 8171; DPI:10.1038/srep08171.
  • Schmauss, C., Lee-McDermott, Z., and Ramos Medina, L. (2014). Trans-generational effects of early life stress: The role of maternal behavior. Sci. Rep. 4, 4873; DOI:10.1038/srep04873.
  • Zimnisky, R., Chang, G., Gyertyán, I., Kiss, B., Adham, N., and Schmauss, C. (2013). Carprazine, a dopamine D3-receptor-preferring partial agonist, blocks PCP-induced impairment of working memory, attention set-shifting, and recognition memory in the mouse. Psychopharmacol. 226: 91-100.
  • Levine, A., Worrell, T.R., Zimnisky, R., and Schmauss, C. (2012). Early life stress triggers sustained changes in histone deacetylase expression and histone H4 modifications that alter responsiveness to adolescent antidepressant treatment. Neurobiol. Dis. 45: 488-498.
  • Mehta, M. and Schmauss, C. (2011). Strain-specific cognitive deficits in adult mice exposed to early life stress. Behav. Neurosci. 125: 29-36.
  • Navailles, S., Zimnisky, R., and Schmauss, C. (2010). Expression of glucocorticoid receptor and early growth response gene 1 during postnatal development of two inbred strains of mice exposed to early life stress. Dev. Neurosci. 32: 139-148.
  • Schmauss, C., Zimnisky, R., Mehta, M, and Shapiro L.P. (2010). The roles of phospholipase C activation and alternative ADAR1 and ADAR2 pre-mRNA splicing in modulating serotonin 2C-receptor editing in vivo. RNA 16: 1779-1785.