Columbia University Medical Center


Charles Zuker, PhD

Charles Zuker, PhD
  • Department of Biochemistry and Molecular Biophysics
  • Department of Neuroscience
  • Professor of Biochemistry and Molecular Biophysics
  • Professor of Neuroscience

The senses of vision, hearing, touch, olfaction, and taste have the critical roles of providing the organism with a faithful representation of the external world. We use a combined molecular, genetic, and physiological approach to investigate the biology of sensory transduction in various systems and model organisms.

Primary Lab Locations

Hammer Health Sciences Building

701 West 168th Street
Room 517A
New York, NY 10032

(212) 305-7921
(212) 342-5747


Member, The Kavli Institute for Brain Science

Lab Website

Research Interests

Brain imaging
Sensory Physiology
Synapses and circuits

Lab Members



  • Chandrashekar, J., et al (2010). The cells and peripheral representation of sodium taste in mice. Nature 464: 297-301.
  • Yarmolinsky, D., C.S. Zuker, and N.J.P. Ryba (2009) Common Sense about Taste: From Mammals to Insects. Cell 139: 234-244.
  • Chandrashekar, J., et al. (2009). The taste of carbonation. Science 326: 443-445.
  • Cook, B., R.W. Hardy, W.B. McConnaughey and C.S. Zuker (2008). Preserving cell shape under environmental stress. Nature 452: 361-364.
  • Chandrashekar, J, M.A. Hoon, N.J.P. Ryba and C.S. Zuker (2006). The receptors and cells for mammalian taste. Nature 444: 288-294.
  • Zelhof, A.C., R.W. Hardy, A. Becker and C.S. Zuker (2006). Transforming the architecture of compound eyes. Nature 443: 696-699.
  • Huang, A.L., X. Chen, M.A. Hoon, J. Chandrashekar, W. Guo, D. Tr√§nkner, N.J.P. Ryba and C.S. Zuker (2006). The cells and logic for mammalian sour taste detection. Nature 442: 934-938.
  • Mueller, K.L., M.A. Hoon, I. Erlenbach, J. Chandrashekar, C.S. Zuker and N.J.P. Ryba (2005). The receptors and coding logic for bitter taste. Nature 434: 225-229.
  • Zhao, G.Q., Y. Zhang, M.A. Hoon, J. Chandrashekar, I. Erlenbach, N.J.P. Ryba and C.S. Zuker (2003). The receptors for mammalian sweet and umami taste. Cell, 115: 255-266.