- Department of Neuroscience
- Department of Psychiatry
Division of Neurobiology and Behavior
- Professor of Neuroscience (in Psychiatry)
Neural circuits controlling behavior have three fundamental properties: Individual components of the circuit form connections with specific partners with appropriate synaptic baselines that can have the capacity to be modified for long durations by activity-dependent mechanisms.
My lab is interested in understanding the cellular and molecular mechanisms that regulate these properties of a behaviorally relevant neural circuit – the sensori-motor synapse – in the marine mollusk Aplysia. Sensory neurons form synapses with specific motor neurons that mature and maintain a synaptic baseline that can be modified in a bidirectional manner for short and long durations by activity known to produce long-lasting bidirectional changes in behavior. We have found that interactions of cell adhesion molecules, activation of sequential cascades of specific signaling pathways involving the timely secretion of neurotrophin-like peptides with autocrine and paracrine actions contribute to these various phases of synapse development and maturation and long-term plasticity associated with behavioral adaptations. We wish to understand how the timely activations of these pathways produce specific regulation of gene transcription/activation, local and cell-wide protein translation, and the network of interacting processes that balance the strength of synapses in a mature neural circuit.
Primary Lab Locations
Kolb Research Annex
40 Haven Avenue
New York, NY 10032
- (646) 774-7326
- Hernandez AI, Wolk J, Hu JY, Schwartz JH, Schacher S (2009). Poly- (ADP-ribose) Polymerase-1 is necessary for long-term facilitation in Aplysia. J Neurosci. 29: 29:9553-9562.
- Hu JY, Chen Y, Bougie JK, Sossin WS, Schacher S (2010). Aplysia cell adhesion molecule and a novel protein kinase C activity in the postsynaptic neuron are required for presynaptic growth and initial formation of specific synapses. J Neurosci 30:8353– 8366.
- Hu JY, Baussi O, Levine A, Chen Y, Schacher S (2011). Persistent long-term synaptic plasticity requires activation of a new signaling pathway by additional stimuli. J Neurosci 31:8842-8850.
- Schacher S, Hu JY (2014) The less things change, the more they are different: the contributions of long-term synaptic plasticity and homeostasis to memory. Learn Mem 21:128-134.
- Hu JY, Schacher S (2014). Persistent long-term facilitation at an identified synapse becomes labile with activation of short-term heterosynaptic plasticity. J Neurosci 34:4776-4785.
- Hu JY, Levine A, Sung Y, Schacher S (2014). cJun and CREB2 in the postsynaptic neuron contribute to persistent long-term facilitation at a behaviorally relevant synapse. J Neurosci 34: in press.