Eric R. Kandel, M.D.University Professor & Kavli Professor of Brain Science, Director, The Kavli Institute for Brain Science
Co-director, The Mind Brain Behavior Initiative, Senior Investigator, Howard Hughes Medical Institute
NYSPI, Unit 21
Tel +1 212-543-5202
Area of Research
Biophysics/Ion Channels, Synapses & Circuits, Neurobiology of Learning & Memory, Animal Models of Psychiatric Disorders, Neurogenetics
Molecular biology of long term memory storage: Initiation and maintenance of synaptic growth; Examination of features shared in simple forms of learning and memory in the Aplysia nervous system and in the mammalian hippocampus.
We combine behavioral, cellular, and molecular biological approaches to delineate the changes that underlie simple forms of learning and memory in invertebrates and vertebrates. In invertebrates the focus of our research is on the gill-withdrawal reflex of Aplysia. We study three elementary forms of learning: habituation, sensitization, and classical conditioning. Recently we have reconstituted critical components of this learning in dissociated cell culture, and we now use the reconstituted system to examine the molecular mechanisms which contribute to short- and long-term memory.
Malleret G, Alarcon JM, Martel G, Takizawa S, Vronskaya S, Yin D, Chen IZ, Kandel ER, Shumyatsky GP. Bidirectional regulation of hippocampal long-term synaptic plasticity and its influence on opposing forms of memory. Journal of Neuroscience 30: 3813-25.