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Charles Zuker

Charles Zuker, Ph.D.

Professor, Biochemistry and Molecular Biophysics; Neuroscience
Member, The Kavli Institute for Brain Science
Hammer Health Sciences Center, Room 517
Tel +1 212-305-7921

Area of Research

Neurogenetics, Sensory Physiology, Brain Imaging


Understanding how the periphery and the brain encode and decode sensory stimuli to orchestrate behavior.


The senses of vision, hearing, touch, olfaction, and taste have the critical roles of providing the organism with a faithful representation of the external world. We use a combined molecular, genetic, and physiological approach to investigate the biology of sensory transduction in various systems and model organisms.


Chandrashekar, J., et al (2010). The cells and peripheral representation of sodium taste in mice. Nature 464: 297-301.

Yarmolinsky, D., C.S. Zuker, and N.J.P. Ryba (2009) Common Sense about Taste: From Mammals to Insects. Cell 139: 234-244.

Chandrashekar, J., et al. (2009). The taste of carbonation. Science 326: 443-445.

Cook, B., R.W. Hardy, W.B. McConnaughey and C.S. Zuker (2008).  Preserving cell shape under environmental stress.  Nature 452: 361-364.

Chandrashekar, J, M.A. Hoon, N.J.P. Ryba and C.S. Zuker (2006). The receptors and cells for mammalian taste. Nature 444: 288-294.

Zelhof, A.C., R.W. Hardy, A. Becker and C.S. Zuker (2006).  Transforming the architecture of compound eyes.  Nature 443: 696-699.

Huang, A.L., X. Chen, M.A. Hoon, J. Chandrashekar, W. Guo, D. Tränkner, N.J.P. Ryba and C.S. Zuker (2006).  The cells and logic for mammalian sour taste detection.  Nature 442: 934-938.

Mueller, K.L., M.A. Hoon, I. Erlenbach, J. Chandrashekar, C.S. Zuker and N.J.P. Ryba (2005). The receptors and coding logic for bitter taste. Nature 434: 225-229.

Zhao, G.Q., Y. Zhang, M.A. Hoon, J. Chandrashekar, I. Erlenbach, N.J.P. Ryba and C.S. Zuker (2003). The receptors for mammalian sweet and umami taste. Cell, 115: 255-266.