header Image
about us faculty training facilities and resources news and calendar contact and directions
Attila Losonczy

Attila Losonczy, M.D., Ph.D.

Assistant Professor, Neuroscience

Hammer Health Sciences Center, Room 510B
Tel +1 212-305-3041
Email 

Area of Research

Neurobiology of Learning & Memory, Synapses & Circuits

Specialization

Synaptic and intrinsic mechanisms of information processing and storage in neural circuits

RESEARCH THEME

A fundamental capacity of the mammalian cerebral cortex is to process information in a form conducive to encoding, storage and  retrieval of memories. A general organizational principle of cortical mnemonic circuits states that these steps all require a precisely orchestrated spatio-temporal interaction among a large number of relatively uniform excitatory and a numerically fewer but richly diverse population of inhibitory and neuromodulatory circuit elements. However,  a mechanistic understanding of how these circuit motifs interact during elementary steps of memory processing is lacking. Our general hypothesis is that single neurons perform complex computations by exploiting their multilayered and compartmentalized dendritic arborization. Specifically, we hypothesize that, (1) neuronal dendritic arbor constitutes a backbone for both compartmentalized input integration and plasticity, and (2) dynamic interactions between synaptic and intrinsic forms of neuronal plasticity can expand neuron’s capability to detect, store and recall various features of information.

To test these predictions, we use a variety of techniques: direct electrophysiological recordings from various compartments of neurons, simultaneous patch-clamp recordings from multiple neurons, together with two-photon imaging/photoactivation and optogenetics.

A major focus of our lab will be to understand how dynamic spatio-temporal interactions among excitatory, inhibitory and neuromodulatory inputs in different subcellular domains fundamentally enhance information processing and storage capabilities of single and small networks of neurons in the hippocampal circuit

Another aspect of our work will focus on testing the prediction that intrinsic and synaptic forms of neuronal plasticity bidirectionally interact within dendritic compartments. We also aim to reveal exact mechanisms how these different forms of neuronal plasticity are affected by inhibition and neuromodulation.

The long-term goal of our laboratory is to establish causal links between single cell computations and behavior.

SELECTED PUBLICATIONS

Makara JK, Losonczy A, Wen Q and Magee JC (2009) Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons (2009). Nature Neuroscience, 12: 1485-1487.

Varga V*, Losonczy A*, Zemelman B*, Borhegyi Z, Nyiri G, Domonkos G, Hangya B, Holderith B,  Magee JC and Freund TF (2009) Fast synaptic subcortical control of hippocampal circuits. Science, 326: 449–453.

Losonczy A*, Makara JK* and Magee JC (2008) Compartmentalized dendritic plasticity and input feature storage in neurons. Nature, 452: 436-441.

Losonczy A, and Magee JC (2006) Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons. Neuron, 50: 291-307.